SCIENTIFIC RESEARCH ON HAIRGENX INGREDIENTS

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1. Fenugreek Seed Extract. (Trigonella foenum-graecum)

  • In vivo Hair Growth Activity of Herbal Formulations

https://scialert.net/fulltext/?doi=ijp.2010.53.57

‘..it can be strongly suggested that the Trigonella has potential components to stimulate the hair growth. It was concluded that Trigonella foenumgraecum showed the best hair growth activity with no skin irritation. It showed minimum time to initiate as well as to complete the hair growth at denuded surfaces. As compared to others, It was also found to improve the hair length also..'

  • Effectiveness test of Fenugreek Seed (Trigonella foenum-graecum L.) Extract hair tonic in Hair Growth Activity:

https://pdfs.semanticscholar.org/d041/7d40660c465157ac1dbff69ea336df7a2334.pdf

'Fenugreek seed extract has a positive effect on hair growth process compared to placebo, with an optimal concentration of 10%.'

  • Fenugreek+micronutrients: Efficacy of a food supplement against hair loss:  

https://www.researchgate.net/publication/251923543_Fenugreekmicronutrients_Efficacy_of_a_food_supplement_against_hair_loss

‘Hair loss, hair thinning, poorly growing hair and powerless or dull hair are common complaints in clinical dermatology. There is a need for products, which support the hair growing process and control some of the disturbances in the hair cycle dynamics. In context of a randomised, placebo-controlled clinical trial efficacy of a fenugreek seeds containing food supplement against hair loss is evaluated. The results indicate a successful treatment of low to moderate hair loss in women and men. Additionally, positive effects on hair growth were demonstrated.’

  • Fenugreek based herbal Shampoos / Conditioners do not contain detergents that can strip up to 80% of the natural hair oils. Formulation of herbal conditioner shampoo by using extract of fenugreek seeds and evaluation of its physicochemical parameters:

https://s3.amazonaws.com/academia.edu.documents/47429338/Formulation_of_herbal_conditioner_shampo20160722-10602-12vmqc6.pdf?response-content-disposition=inline%3B%20filename%3DFormulation_of_herbal_conditioner_shampo.pdf&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIAIWOWYYGZ2Y53UL3A%2F20200211%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Date=20200211T092426Z&X-Amz-Expires=3600&X-Amz-SignedHeaders=host&X-Amz-Signature=fa919f7adbfecd3f56ab42d44750cacf14f5649cc59068c1cbf5e1fcb428dcb0

In this study, it was demonstrated that 95% of applicants were happy with hair combing comfort, smooth and shiny hair and lack of static electricity in their hair. In this study, hair conditioning was demonstrated, because of the existence of trigonelline in fenugreek extract. It also showed that our product makes high volume of foam and all consumers showed it in their questionnaires and this is also because of saponin in fenugreek extract. Based on this and other studies, it appeared that the use of herbal shampoo is better than a synthetic shampoo (Cerchiaraa et al., 2010; Glassman, 1997). Some shampoos contain high volume of detergent and it removes more than 80% of oil from hair but there is no such problem in the use of herbal shampoos. It is recommended that it is better to use herbal extract like fenugreek extract rather than using other chemical because herbal shampoos are safer and healthier (Mainkar et al., 2001).

  • Trigonella (Fenugreek) Improves Sexual Function in Women

https://www.naturalhealthresearch.org/trigonella-improves-sexual-function-women-directors-choice/

For the researchers, “This study has provided further evidence that T. foenum-graecum seed extract is a well-tolerated and effective botanical medicine for use in the support of sexual function of pre-menopausal women, in particular increasing sexual desire and arousal, with positive effects on concentrations of E2 and free testosterone.”

(Note: 600mg taken for this study. Hairgenx dosage 300/450mg)

  • Physiological aspects of male libido enhanced by standardized Trigonella foenum-graecum extract and mineral formulation.

https://www.ncbi.nlm.nih.gov/pubmed/21312304

Testofen, a standardized Trigonella foenum-graecum (Fenugreek) extract had an overall positive effect on physiological aspects of libido. In particular, there was a significant increase in the subdomains of sexual arousal and orgasm. Testofen had a positive effect on QOL in self-reported satisfaction with muscle strength, energy and well-being but did not have an effect on mood or sleep. Serum prolactin and testosterone levels remained within the reference range. It was concluded that Testofen demonstrated a significant positive effect on physiological aspects of libido and may assist to maintain normal healthy testosterone levels.

(Note: 600mg taken for this study. Hairgenx dosage 300/450mg)

2. He Shou Wu (Polygonum multiflorum) 

  • Hair Growth Promotion Activity and Its Mechanism of Polygonum multiflorum:

https://www.researchgate.net/publication/281138363_Hair_Growth_Promotion_Activity_and_Its_Mechanism_of_Polygonum_multiflorum

..‘Many studies had found that FGF (fibroblast growth factor) shows obvious adjustment to the hair growth. FGF could promote hair to enter the anagen stage and increase hair follicles amounts. Vascular endothelial growth factor (VEGF), a multifunctional cytokine, could not only induce the formation of blood vessels around hair follicles, but also promote directly the dermal papilla cells proliferation’

  • Polygonum Multiforum and potential role in hair growth:

https://ugro.com/the-research-behind-polygonum-multiflorum-hair-loss-benefits/

‘A  large study was conducted on 507 participants to observe the effects of Fo Ti or Polygonum multiflorum on hair loss, when taken orally (1). After collecting and analyzing their data, the researchers found:

  • 77% of the participants experienced significantly reduced hair loss.
  • 95% of the subjects noticed that issues with excessive shedding had stopped.
  • 90% of the men and women who took part in this study displayed noticeable improvement in new growth after 6 months of taking the polygonum multiflorum hair loss treatment.’

3. Nettle Root Extract (Urtica dioica) (In combination with Betasitosteral)

  • Proprietary Herbal Extract Down regulates the Gene Expression of IL-1α in HaCaT Cells: Possible Implications Against Non scarring Alopecia:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126931/

‘Among the plants used in our formulation Urtica dioica (Ud) is the most widely studied one. Symptomatic benign prostate hyperplasia (BPH) is the best researched indication of this plant which is mainly due to its 5α-R inhibition activity (23, 24, 25). Inhibition of 5α-R precludes the conversion of testosterone to dihydrotestosterone (DHT) high levels of which are associated with BPH (26). The same pathogenesis is also valid for AGA (3,4). Although Ud leaves have traditionally been used for hair loss, confirmatory clinical trials are still lacking (26). In a study performed with a combination of herbal extracts including Ud, the combination was found to increase the proliferation of human dermal papilla cells significantly at concentrations ranging from 1.5% to 4.5% (27). Ud contains β sitosterol which stimulates angiogenesis by increasing vascular endothelial growth factor (VEGF) synthesis and supports new hair growth (28).’

4. Pygeum (Pygeum Africanum)

  • Pygeum Africanum: Natural DHT Blocker and Hair Loss Treatment:

https://tophairlosstreatments.com/pygeum-africanum-dht-hair-loss/

Men using Pygeum africanum were more than twice as likely to report an improvement in overall [BPH] symptoms […] Adverse effects due to Pygeum Africanum were mild and comparable to placebo.” This is relevant to hair loss sufferers as both BPH and androgenetic alopecia are linked to DHT. A reduction in DHT almost always means a reduction in BPH symptoms, suggesting Pygeum africanum may work by reducing levels of this hormone.

5. Horsetail (Equisetum arvense)

  • Inhibition of 5α-Reductase, IL-6 Secretion, and Oxidation Process of Equisetum debile Roxb. ex Vaucher Extract as Functional Food and Nutraceuticals Ingredients:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691721/

‘According to the highest inhibitory activity against 5α-reductase and lipid peroxidation, as well as, high IL-6 secretion reduction, EA was the most attractive extract for anti-hair loss.’

6. Saw Palmetto 25% Berry Extract (Serenoa Repens)

  • Serenoa repens extracts promote hair regeneration and repair of hair loss mouse models by activating TGF-β and mitochondrial signaling pathway:

https://www.ncbi.nlm.nih.gov/pubmed/29949176

‘LSESr (liposterolic extracts of Serenoa repens ) promoted the hair regeneration and repair of hair loss mouse models by activating TGF-β signaling and mitochondrial signaling pathway.’

7. Betasitosterol   

  • Proprietary Herbal Extract Downregulates the Gene Expression of IL-1α in HaCaT Cells: Possible Implications Against Non scarring Alopecia:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126931

‘..contains β sitosterol which stimulates angiogenesis by increasing vascular endothelial growth factor (VEGF) synthesis and supports new hair growth (28).’

8. Biotin/zinc

  • Serum biotin and zinc in male androgenetic alopecia:

https://www.ncbi.nlm.nih.gov/pubmed/30714301

‘Serum biotin showed a suboptimal level in MAGA (Male androgenetic alopecia) patients that is not correlated with patients' age or disease severity. Biotin supplement in MAGA treatment may add value to hair quality and texture. 

  • A review of the use of Biotin for Hair Loss:

https://www.karger.com/Article/Abstract/462981

Results: We found 18 reported cases of biotin use for hair and nail changes. In all cases, patients receiving biotin supplementation had an underlying pathology for poor hair or nail growth. All cases showed evidence of clinical improvement after receiving biotin