SCIENTIFIC RESEARCH ON HAIRGENX INGREDIENTS

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1. Fenugreek Seed Extract. (Trigonella foenum-graecum)

https://scialert.net/fulltext/?doi=ijp.2010.53.57

‘..it can be strongly suggested that the Trigonella has potential components to stimulate the hair growth. It was concluded that Trigonella foenumgraecum showed the best hair growth activity with no skin irritation. It showed minimum time to initiate as well as to complete the hair growth at denuded surfaces. As compared to others, It was also found to improve the hair length also..'

https://www.researchgate.net/publication/251923543_Fenugreekmicronutrients_Efficacy_of_a_food_supplement_against_hair_loss

‘Hair loss, hair thinning, poorly growing hair and powerless or dull hair are common complaints in clinical dermatology. There is a need for products, which support the hair growing process and control some of the disturbances in the hair cycle dynamics. In context of a randomised, placebo-controlled clinical trial efficacy of a fenugreek seeds containing food supplement against hair loss is evaluated. The results indicate a successful treatment of low to moderate hair loss in women and men. Additionally, positive effects on hair growth were demonstrated.’

2. He Shou Wu (Polygonum multiflorum)  

https://www.researchgate.net/publication/281138363_Hair_Growth_Promotion_Activity_and_Its_Mechanism_of_Polygonum_multiflorum

..‘Many studies had found that FGF (fibroblast growth factor) shows obvious adjustment to the hair growth. FGF could promote hair to enter the anagen stage and increase hair follicles amounts. Vascular endothelial growth factor (VEGF), a multifunctional cytokine, could not only induce the formation of blood vessels around hair follicles, but also promote directly the dermal papilla cells proliferation’

https://ugro.com/the-research-behind-polygonum-multiflorum-hair-loss-benefits/

‘A  large study was conducted on 507 participants to observe the effects of Fo Ti or Polygonum multiflorum on hair loss, when taken orally (1). After collecting and analyzing their data, the researchers found:

  • 77% of the participants experienced significantly reduced hair loss.
  • 95% of the subjects noticed that issues with excessive shedding had stopped.
  • 90% of the men and women who took part in this study displayed noticeable improvement in new growth after 6 months of taking the polygonum multiflorum hair loss treatment.’

3. Nettle Root Extract (Urtica dioica) (In combination with Betasitosteral)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126931/

‘Among the plants used in our formulation Urtica dioica (Ud) is the most widely studied one. Symptomatic benign prostate hyperplasia (BPH) is the best researched indication of this plant which is mainly due to its 5α-R inhibition activity (23, 24, 25). Inhibition of 5α-R precludes the conversion of testosterone to dihydrotestosterone (DHT) high levels of which are associated with BPH (26). The same pathogenesis is also valid for AGA (3,4). Although Ud leaves have traditionally been used for hair loss, confirmatory clinical trials are still lacking (26). In a study performed with a combination of herbal extracts including Ud, the combination was found to increase the proliferation of human dermal papilla cells significantly at concentrations ranging from 1.5% to 4.5% (27). Ud contains β sitosterol which stimulates angiogenesis by increasing vascular endothelial growth factor (VEGF) synthesis and supports new hair growth (28).’

4. Pygeum (Pygeum Africanum)

https://tophairlosstreatments.com/pygeum-africanum-dht-hair-loss/

Men using Pygeum africanum were more than twice as likely to report an improvement in overall [BPH] symptoms […] Adverse effects due to Pygeum Africanum were mild and comparable to placebo.” This is relevant to hair loss sufferers as both BPH and androgenetic alopecia are linked to DHT. A reduction in DHT almost always means a reduction in BPH symptoms, suggesting Pygeum africanum may work by reducing levels of this hormone.

5. Horsetail (Equisetum arvense)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691721/

‘According to the highest inhibitory activity against 5α-reductase and lipid peroxidation, as well as, high IL-6 secretion reduction, EA was the most attractive extract for anti-hair loss.’

6. Saw Palmetto 25% Berry Extract (Serenoa Repens)

https://www.ncbi.nlm.nih.gov/pubmed/29949176

‘LSESr (liposterolic extracts of Serenoa repens ) promoted the hair regeneration and repair of hair loss mouse models by activating TGF-β signaling and mitochondrial signaling pathway.’

7. Betasitosterol   

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126931

‘..contains β sitosterol which stimulates angiogenesis by increasing vascular endothelial growth factor (VEGF) synthesis and supports new hair growth (28).’

8. Biotin/zinc

https://www.ncbi.nlm.nih.gov/pubmed/30714301

‘Serum biotin showed a suboptimal level in MAGA (Male androgenetic alopecia) patients that is not correlated with patients' age or disease severity. Biotin supplement in MAGA treatment may add value to hair quality and texture. We recommend future biotin evaluation in serum combined with its metabolites in MAGA patients' urine.